Advances in Arrhythmia and Electrophysiology Premature Ventricular Contraction-Induced Cardiomyopathy A Treatable Condition

Premature ventricular contraction-induced cardiomyopathy: a treatable condition.

Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricle. They are often seen in association with structural heart disease and represent increased risk of sudden death,1 yet they are ubiquitous, even in the absence of identifiable heart disease.1,2 They may cause troubling and sometimes incapacitating symptoms such as palpitations, chest...

Association between cytokines and two circulating micro-RNAs and development of premature ventricular contractions-induced cardiomyopathy

Objective(s): Recent progress in understanding the pathogenesis of premature ventricular contraction (PVC)-induced cardiomyopathy (PIC) has suggested a key role for inflammation. The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-α) and interferon-γ (...

Premature ventricular contraction-induced symptomatic slow pathway conduction successfully treated by catheter ablation.

Abnormal Left Ventricular Mechanics of Ventricular Ectopic Beats: Insights Into Origin and Coupling Interval in Premature Ventricular Contraction-Induced Cardiomyopathy.

BACKGROUND Left ventricular (LV) dyssynchrony caused by premature ventricular contractions (PVCs) has been proposed as a mechanism of PVC-induced cardiomyopathy. We sought to understand the impact of different PVC locations and coupling intervals (prematurity) on LV regional mechanics and global function of the PVC beat itself. METHODS AND RESULTS Using our premature pacing algorithm, pentage...

Eliminating ventricular tachycardia by targeting premature ventricular contractions in arrhythmogenic right ventricular dysplasia/cardiomyopathy: innocent bystander or heart of the matter?